Atletico Madrid coach Diego Simeone urged his players to quickly switch focus onto their Champions League clash with Real Madrid rather than getting carried away with Saturday's 1-0 home win over Athletic Bilbao that provisionally lifted his team to the top of La Liga.

Atletico faces Real in the first leg of the Champions League last-16 in a mouth-watering Madrid derby, something Simeone is wary of despite his team's good form.

"We have a big game in the Champions League and at the moment we just have to focus on that and get well rested during these three days off," Simeone told a news conference.

"What we have to do at the moment is continue to strengthen the collective work of the players and not lose that focus."

Simeone also hailed substitute Julian Alvarez, who sealed the victory minutes after coming on for Alexander Sorloth just before the hour mark.

"Today we faced a very difficult opponent. They defended well and had some good chances with Nico and Inaki Williams. We were lucky to have Julian in the second half and for him to finish the counter-attack the way he did," he said.

The manager added that he was thrilled when his compatriot joined the team after leaving Manchester City.

"Sometimes players come in, they are special and as a coach you know that. They are different and, well, I like their modesty and I love their versatility," he said.

Atletico tops La Liga with 56 points, two clear of Barcelona, and third-placed Real Madrid, who lost 2-1 at Real Betis on Saturday.

Real stumbles

La Liga champion Real Madrid suffered a 2-1 defeat at Real Betis, which coach Carlo Ancelotti said was a "big blow" to its title defense.

For Betis, Isco scored the winner from the penalty spot against his former side Madrid.

Ancelotti picked a strong lineup, with no breathing room in the title race, despite the impending Champions League clash against Atletico.

"If we play like this on Tuesday we will not win," said Ancelotti, whose side has one win in its last five La Liga matches.

The visitor took the lead at the Benito Villamarin stadium through Brahim Diaz but Betis struck back with a Johnny Cardoso header, as Real Madrid missed the suspended Jude Bellingham.

Isco secured the Andalusian side a deserved victory with a penalty early in the second half.

"It's a big blow. We have to react," continued Ancelotti.

"We started well, but later we did not have the same level of commitment, the game got out of control against a side that played better than us and deserved to win."

Isco returned to action in December after missing several months with a broken leg and has hit top form in recent weeks.

"About halfway through the first half we stepped up our game, and I'm happy with the win against the best team around these days," said the playmaker, who won several major trophies with Real Madrid before departing in 2022.

Madrid started stronger and opened the scoring after just 10 minutes, putting together a fine team move with 19 passes.

It culminated when Kylian Mbappe found Ferland Mendy, who squared for Diaz to tuck home.

Betis soon found its footing and Cardoso powered a header past Thibaut Courtois from Isco's corner to level.

Without Bellingham's dynamism in midfield Madrid was outfought by Betis.

Manuel Pellegrini's side took the lead early in the second half from the penalty spot when Antonio Rudiger crashed into Jesus Rodriguez as he ran in on goal.

Isco smashed home for his sixth goal across all competitions.

For the final 15 minutes, Ancelotti replaced Mbappe, who had dental trouble ahead of the game, with Endrick.

"He had that (tooth) problem, he hadn't trained a lot," explained Ancelotti. "He was not at his best level."

'Goddess of fortune'

Atletico held its nerve at the Metropolitano Stadium to take a provisional lead in the title race.

After substitute Alvarez struck, the Basque side hit the woodwork three times in the hunt for an equalizer.

"It's an incredibly important win, we knew it would not be easy," Alvarez told Movistar.

"We're in the fight for the title, but we know there's a long way to go, a lot of very important games are coming close together, but with hard work and humility we'll achieve (our goals)."

Atletico goalkeeper Jan Oblak made a fine save to deny Inaki Williams early on, in an even first half.

The Rojiblancos have often relied on their substitutes making huge impacts this season and so it proved again as they opened the scoring.

Simeone brought on Marcos Llorente and Alvarez just before the hour mark and the duo combined to open the scoring after 66 minutes.

Llorente delivered a fine low pass for the former Manchester City striker to run on to, and he finished with minimal fuss for his eighth league goal of the campaign.

Athletic came millimeters away from an equalizer when Benat Prados headed against the post with Oblak beaten and Williams crashed the rebound off the underside of the crossbar and out.

"In the second half our changes helped us, Oblak too, and the goddess of fortune with the shots that hit the post and the bar," said Simeone.

Ghana international Williams hit the woodwork once again with a deflected strike from range and Athletic left frustrated.

"I think we deserved a lot more, we had more chances than them, but it's not about who deserves what, it's about putting them away," Williams told Movistar.

Agencies